How can monkeypox be differentiated from smallpox?

A) By the severity of symptoms

B) By the appearance and progression of the rash

C) By laboratory testing

D) All of the above

Answer: D) All of the above

Explanation: Monkeypox and smallpox can be differentiated through a combination of clinical features, the progression of the rash, severity of symptoms, and laboratory testing (e.g., PCR testing). Both diseases have similar initial presentations, but differences exist in rash characteristics and progression.