What is a significant difference between monkeypox and chickenpox?

A) Mode of transmission

B) Type of virus

C) Rash appearance

D) All of the above

Answer: D) All of the above

Explanation: Monkeypox and chickenpox differ in mode of transmission, type of virus (monkeypox is a DNA virus while chickenpox is a varicella-zoster virus), and the appearance of the rash.